ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences
Progressive multifocal leukoencephalopathy
Print
Other Resources UpToDate PubMed

Progressive multifocal leukoencephalopathy

Print Images (1)
Contributors: Andrea Wasilewski MD, Jamie Adams MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed

Synopsis

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by reactivation of John Cunningham (JC) virus, which destroys oligodendrocytes. It is associated with human immunodeficiency virus (HIV) / AIDS, usually in patients with CD4 counts less than 200, and can also occur after initiation of highly active antiretroviral therapy. In addition, the disease is seen after treatment with immune-modulating therapies such as natalizumab.

Focal neurologic symptoms are typically subacute and evolve over weeks. Symptoms can include weakness, sensory loss, ataxia, vision changes, aphasia, cognitive decline, or behavioral changes. Seizures can also occur.

PML classically affects the subcortical white matter and U-fibers. Prognosis depends on severity of the underlying disease, although it is generally poor, and the disease is often fatal within months.

Codes

ICD10CM:
A81.2 – Progressive multifocal leukoencephalopathy

SNOMEDCT:
22255007 – Progressive multifocal leukoencephalopathy

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Updated: 09/12/2018
Copyright © 2019 VisualDx®. All rights reserved.
Progressive multifocal leukoencephalopathy
Print 1 Images
Progressive multifocal leukoencephalopathy : Aphasia, Ataxia, Extremities weakness, Mental status alteration, Visual impairment, Asthenia, Cognitive decline
Copyright © 2019 VisualDx®. All rights reserved.