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Progressive supranuclear palsy
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Progressive supranuclear palsy

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Contributors: Jamie Adams MD, Richard L. Barbano MD, PhD
Other Resources UpToDate PubMed

Synopsis

Progressive supranuclear palsy is a neurodegenerative disorder caused by destruction of brain cells, primarily in the brain stem, and accumulation of tau protein. Average age of onset is 60-65 years, and it is more common in men. Symptoms include parkinsonism (bradykinesia, rigidity, with or without tremor), axial rigidity, gait / postural instability and early falls, eye movement abnormalities, blurry vision, blepharospasm, eyelid opening apraxia, dysarthria, dysphagia, retrocollis, cognitive decline, depression, anxiety, apathy, behavioral changes, and pseudobulbar palsy.

Lack of response to levodopa is common. Prognosis is poor; most patients are significantly disabled within 5 years of diagnosis and die within 10 years of diagnosis.

For more information, see OMIM.

Codes

ICD10CM:
G23.1 – Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]

SNOMEDCT:
192976002 – Progressive supranuclear palsy

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Last Reviewed: 10/19/2018
Last Updated: 01/04/2019
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Progressive supranuclear palsy
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Progressive supranuclear palsy : Dysarthria, Gait disturbance, Dysphagia, Axial rigidity
Copyright © 2019 VisualDx®. All rights reserved.