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Prostate cancer
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Prostate cancer

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Contributors: Michael W. Winter MD, Benjamin L. Mazer MD, MBA
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Prostate cancer is malignant neoplasm, most commonly adenocarcinoma; sarcomas and small cell cancers are rarely observed. It is the most common noncutaneous cancer affecting men. Mortality rate is approximately 20%. Affected patients are asymptomatic until the disease has reached an advanced stage. Screening with prostate-specific antigen reveals abnormalities in the serum and assists in early diagnosis.

Initial physical findings may include perineal pain and urinary changes (frequency, retention, nocturia). Urinary changes in men are more frequently the result of benign prostate conditions, which are sometimes found as comorbidities. Physical exam may reveal areas of induration, asymmetry, and/or prostate nodule. Diagnosis is confirmed via prostate biopsy.

Risk factors include advancing age, family history, obesity, poor diet, elevated insulin levels, and vitamin E supplementation. Disease is more common in individuals of African descent. Men with BRCA mutations, primarily BRCA2 mutations, are at increased risk of prostate cancer. Treatment depends on the level of risk and the age of the patient.

If cancer has spread, physical findings may include bone pain or pathologic fracture. See metastatic prostate carcinoma.


C61 – Malignant neoplasm of prostate

399068003 – Malignant tumor of prostate

Differential Diagnosis & Pitfalls

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Updated: 08/29/2019
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Prostate cancer
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Prostate cancer : Bone pain, Urinary frequency, Urinary retention, Weight loss, Pelvic mass, Nocturia
Imaging Studies image of Prostate cancer
Axial CT image demonstrates an enlarged, bulky prostate gland which indents the bladder wall. Biopsy was consistent with prostate carcinoma.
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