Pseudolymphoma in Adult
Triggers include insect bites or stings, which cause local reactions, or anticonvulsant drugs, which can cause widespread eruptions. Other causes include a broad range of non-anticonvulsant drugs (antihypertensives, lipid lowering agents, and antidepressants, among others), tattoo dyes, trauma, vaccinations, contact dermatitis, folliculitis, and infections (such as varicella, molluscum contagiosum, human immunodeficiency virus [HIV], or Lyme disease). Pseudolymphoma may be seen after scabies infection, particularly in children. Medication-related reactions may include fever, lymphadenopathy, and an erythematous skin eruption. Malaise, arthralgia, hepatosplenomegaly, eosinophilia, and abnormal liver function tests can also be present in medication-related cases.
While pseudolymphoma may occur at any age, it is most commonly seen in early adulthood.
L98.8 – Other specified disorders of the skin and subcutaneous tissue
19750001 – Pseudolymphoma
Differential Diagnosis & Pitfalls
- Insect bite – Can be multiple.
- Fixed drug reaction
- Mycosis fungoides
- Cutaneous B-cell lymphoma
- Non-Hodgkin lymphoma
- Lymphocytic infiltrate of Jessner
- Nodular scabies / scabies (pediatric) – Extremely pruritic.
- Lymphomatoid papulosis – Some of the papules are crusted with necrotic centers.
- Lymphomatoid granulomatosis
- Actinic reticuloid (see chronic actinic dermatitis)
- Follicular mucinosis
- Tumid lupus
- Sweet syndrome
Drug Reaction Data