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Pseudolymphoma in Child
Other Resources UpToDate PubMed

Pseudolymphoma in Child

Contributors: Jeffrey M. Cohen MD, Belinda Tan MD, PhD, Susan Burgin MD
Other Resources UpToDate PubMed


Pseudolymphoma (cutaneous lymphoid hyperplasia) is a benign inflammatory response that histologically and often clinically mimics cutaneous lymphoma. Both T-cell and B-cell forms of pseudolymphoma may be seen. Pseudolymphoma is characterized by dense lymphoid infiltrates of the skin, which may be focal or diffuse.

Triggers include insect bites or stings, which cause local reactions, or anticonvulsant drugs, which can cause widespread eruptions. Other causes include a broad range of non-anticonvulsant drugs (antihypertensives, lipid lowering agents, and antidepressants, among others), tattoo dyes, trauma, vaccinations, contact dermatitis, folliculitis, and infections (such as varicella, molluscum contagiosum, human immunodeficiency virus [HIV], or Lyme disease). Pseudolymphoma may be seen after scabies infection, particularly in children. Medication-related reactions may include fever, lymphadenopathy, and an erythematous skin eruption. Malaise, arthralgia, hepatosplenomegaly, eosinophilia, and abnormal liver function tests can also be present in medication-related cases.

While pseudolymphoma may occur at any age, it is most commonly seen in early adulthood.


L98.8 – Other specified disorders of the skin and subcutaneous tissue

19750001 – Pseudolymphoma

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Arthropod bite or sting – Can be multiple.
  • Fixed drug eruption
  • Cutaneous T-cell lymphoma
  • Cutaneous B-cell lymphoma
  • Non-Hodgkin lymphoma
  • Jessner benign lymphocytic infiltrate
  • Sarcoidosis
  • Scar
  • Nodular Scabies / Scabies – Extremely pruritic.
  • Lymphomatoid papulosis – Some of the papules are crusted with necrotic centers.
  • Lymphomatoid granulomatosis
  • Actinic reticuloid (see Chronic actinic dermatitis)
  • Alopecia mucinosa
  • Tumid lupus erythematosus
  • Secondary syphilis
  • Acute febrile neutrophilic dermatosis

Best Tests

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Management Pearls

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Reviewed:02/06/2018
Last Updated:03/20/2023
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Pseudolymphoma in Child
A medical illustration showing key findings of Pseudolymphoma : Face, Lymphadenopathy, Neck, Smooth nodule, Superior chest, Upper back
Clinical image of Pseudolymphoma - imageId=209984. Click to open in gallery.  caption: 'A close-up of a reddish nodule that was rubbery on palpation (with surrounding tiny seborrheic keratoses and a pink pedunculated nevus).'
A close-up of a reddish nodule that was rubbery on palpation (with surrounding tiny seborrheic keratoses and a pink pedunculated nevus).
Copyright © 2024 VisualDx®. All rights reserved.