Pseudomonas hot-foot syndrome is a skin infection of the soles caused by Pseudomonas aeruginosa. It is characterized by painful erythematous plantar nodules, typically occurring in children following use of Pseudomonas-contaminated pools. Similar involvement of the palms has been reported less frequently. It is clinically distinct from folliculitis caused by Pseudomonas.

This condition typically occurs in young children. It is thought that children may have a thinner epidermis on their palms and soles compared with adults, and also that they may be more active in pool areas; this increases the risk for friction injuries and susceptibility to infection.

Symptoms typically occur 6-48 hours following exposure to contaminated pools and include intense pain followed by swelling, redness, and warmth in the affected areas. Clinical course is usually benign, with rapid resolution. The condition does not typically require antibiotic therapy; however, leukocytosis and low-grade fevers may occur with infection, and antibiotics may be given in more severe cases.

Infections typically occur as outbreaks, with history revealing use of the same contaminated pool or hot tub.