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Pyodermatitis vegetans
Other Resources UpToDate PubMed

Pyodermatitis vegetans

Contributors: Vivian Wong MD, PhD, Kira Blair Mayo MD, Carl Allen DDS, MSD, Sook-Bin Woo MS, DMD, MMSc, Susan Burgin MD
Other Resources UpToDate PubMed


Pyodermatitis vegetans (PDV) is a rare inflammatory disorder that is often associated with underlying inflammatory bowel disease (IBD), particularly ulcerative colitis, and less commonly with primary sclerosing cholangitis. Men are more frequently affected than women, and patients are usually aged 20-60 years when diagnosed. The onset of bowel disease can precede this disease by years. PDV may also be a marker of subclinical disease. Most patients with PDV develop mucosal lesions as well. The term pyostomatitis-pyodermatitis vegetans (PSV-PDV) is used in cases of mucocutaneous disease. The pathogenesis of PSV and PDV is poorly understood.

Related topic: pyostomatitis vegetans


L08.81 – Pyoderma vegetans

14800001 – Dermatitis vegetans

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Differential Diagnosis & Pitfalls

  • Orofacial herpes simplex virus
  • Pemphigus vegetans
  • Pemphigus foliaceus
  • Pemphigus erythematosus
  • Hailey-Hailey disease
  • Seborrheic dermatitis
  • Reactive infectious mucocutaneous eruption (RIME)
  • IgA pemphigus
  • Subcorneal pustular dermatosis
  • Pyoderma gangrenosum
  • Blastomycosis-like pyoderma
  • Iododerma
  • Erosive pustular dermatosis
  • Amicrobial pustulosis of the folds
  • Hidradenitis suppurativa

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Last Reviewed:05/11/2020
Last Updated:02/17/2022
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Pyodermatitis vegetans
A medical illustration showing key findings of Pyodermatitis vegetans
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