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Radiation nephropathy
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Radiation nephropathy

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Contributors: Casey Silver MD, Catherine Moore MD, Michael W. Winter MD
Other Resources UpToDate PubMed

Synopsis

Radiation nephropathy is characterized by kidney dysfunction following external radiation with no histologic evidence of inflammation.

Clinical presentations include:
  • Acute nephropathy – Abrupt onset after a 6- to 12-month latent period following radiation exposure.
  • Chronic nephropathy – May follow an acute episode or may follow a more indolent course, presenting more than 12 months after radiation exposure.
  • Benign or malignant hypertension – May occur from 18 months to years after radiation exposure.
  • Asymptomatic proteinuria – Frequently intermittent, this may be the only sign.
Common signs and symptoms are severe anemia, hypertension, and increased serum creatinine. Symptoms may also include microscopic hematuria and edema.

Codes

ICD10CM:
N14.4 – Toxic nephropathy, not elsewhere classified
T66.XXXA – Radiation sickness, unspecified, initial encounter

SNOMEDCT:
236514003 – Toxic nephropathy

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

In bone-marrow transplant patients who develop chronic kidney disease, consider: Differential diagnosis also includes:

Best Tests

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Management Pearls

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Therapy

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References

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Last Reviewed: 04/12/2019
Last Updated: 05/08/2019
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Radiation nephropathy
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Radiation nephropathy : Fatigue, Creatinine elevated, Edema, Hyperkalemia, Proteinuria, Dyspnea, BP increased
Copyright © 2019 VisualDx®. All rights reserved.