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Red scrotum syndrome - Anogenital in
See also in: Cellulitis DDx
Other Resources UpToDate PubMed

Red scrotum syndrome - Anogenital in

See also in: Cellulitis DDx
Contributors: Jourdan Brandon, Asha Nanda, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Red scrotum syndrome (RSS), also known as male genital dysesthesia, is characterized by persistent erythema of the scrotum, burning pain, and hyperalgesia. The pathophysiology of RSS is poorly understood, but proposed causes include rebound vasodilation after chronic topical corticosteroid use, localized erythromelalgia, and neurogenic inflammation.

White men older than 50 have the highest incidence of this condition, but cases have been reported in younger individuals. Patients commonly present with scrotal erythema and burning pain with a preceding history of topical corticosteroids on the affected area. The average duration of topical corticosteroid use is 27 months, but cases of RSS have occurred after as few as 2 weeks. RSS can develop after prolonged use of topical corticosteroids with a potency as low as over-the-counter hydrocortisone cream. A common complaint is difficulty sitting normally due to pressure on the scrotum causing pain. RSS is a chronic condition that is difficult to treat, which can cause profound psychological distress.

RSS is thought to be part of red burning skin syndrome, which describes other presentations of rebound vasodilation following chronic use of topical corticosteroids, including red face syndrome, red scalp syndrome, red ear syndrome, and red vulva syndrome.

Codes

ICD10CM:
L53.9 – Erythematous condition, unspecified
N50.89 – Other specified disorders of the male genital organs

SNOMEDCT:
238969001 – Burning scrotum
65645005 – Scrotal pruritus

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed:10/31/2022
Last Updated:11/13/2022
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Red scrotum syndrome - Anogenital in
See also in: Cellulitis DDx
A medical illustration showing key findings of Red scrotum syndrome : Erythema, Scrotum, Pruritus
Clinical image of Red scrotum syndrome - imageId=2046108. Click to open in gallery.  caption: 'Diffuse bright red erythema of the scrotum.'
Diffuse bright red erythema of the scrotum.
Copyright © 2022 VisualDx®. All rights reserved.