RV can affect blood vessels of any size and can cause clinical manifestations corresponding to the size of the blood vessels affected. It most commonly presents with petechiae and palpable purpura, which are manifestations of small-vessel disease. In severe presentations of RV characterized by medium-vessel involvement, nodules, ulcerations, infarctions, and necrosis can occur, reminiscent of polyarteritis nodosa. Manifestations of RV visceral organ involvement include aortitis, peripheral neuropathy, pericarditis, glomerulonephritis, scleritis, and gastrointestinal bleeding.
Genetic factors such as major histocompatibility (MHC) isoforms contribute to RV disease susceptibility. Thus far, cigarette smoking is the only environmental factor implicated in disease pathogenesis. Numerous viral infections and medications have been hypothesized to be triggers for RV without conclusive evidence.
M05.20 – Rheumatoid vasculitis with rheumatoid arthritis of unspecified site
400054000 – Rheumatoid vasculitis
Differential Diagnosis & Pitfalls