Schistosomiasis is endemic in many parts of Africa, South America, the Caribbean, China, Southeast Asia, and the Middle East. Infection is more prevalent in those living in tropical and subtropical areas lacking adequate sanitation. Travelers to endemic regions who are exposed to contaminated water are also at risk. Over 200 million people are infected worldwide.
After development in the intermediate aquatic snail host, parasites are released into fresh water as cercariae. They penetrate the skin and become schistosomula. They then migrate to the liver and become adult trematodes (1-3 cm long). Mating adults migrate to venules of the genitourinary tract (in the case of Schistosoma haematobium) and gastrointestinal tract (in the case of Schistosoma mansoni, Schistosoma japonicum, Schistosoma intercalatum, and Schistosoma mekongi) where they produce eggs that are shed in the urine and feces, respectively. After infected individuals urinate or defecate in the water, eggs hatch, reinfecting the snails.
Within a few days after exposure, an individual may develop a rash that then clears. Acute schistosomiasis may be asymptomatic or it may cause a systemic allergic reaction, especially in individuals who are visiting endemic areas on first exposure. It occurs approximately 1 month after exposure when adult parasites begin laying eggs. Urticaria, fever, sweats, chills, cough, and headache are accompanied by lymphadenopathy and hepatosplenomegaly. Respiratory and gastrointestinal symptoms may also occur. This syndrome is known as Katayama fever. It is usually seen with S. japonicum infection, but more recently cases from S. mansoni have also been recognized.
Without treatment, chronic disease will develop and may persist for years. Complications of chronic schistosomiasis occur as a result of the granulomatous response to eggs in affected tissues and subsequent fibrosis. Liver, intestine, spleen, lungs, and bladder can be involved. Chronic bladder involvement leads to an increased risk of bladder cancer. Rarely, there may be central nervous system (CNS) involvement, causing myelopathy, seizures, or paralysis.
All ages and sexes are susceptible. However, the prevalence and severity is highest in children and slowly declines with age.
It has been shown that women and men with lower urinary schistosomiasis have a significantly increased risk of acquiring, and subsequently transmitting, human immunodeficiency virus (HIV) to their sexual partners.
B65.9 – Schistosomiasis, unspecified
10087007 – Schistosomiasis
- Cercarial dermatitis (swimmer's itch) from schistosomal species that infect birds or mammals other than humans.
- Seabather's eruption
- Arthropod bites
- Drug eruption
- Atopic dermatitis (papular variant)
- Viral exanthem
- Typhoid fever
- Dengue fever
- Yellow fever
- Trench fever
- Other bacterial, viral, fungal, and protozoal fevers
Neuroschistosomiasis (NSS) should be included in the differential diagnosis in HIV-infected patients from endemic areas who display an acute encephalopathy. While CT scan and MRI are useful tools in the investigation of NSS, the definitive diagnosis is based on the direct identification of the eggs in tissue biopsy.
Last Updated: 01/29/2018