ICD10CM:
L21.9 – Seborrheic dermatitis, unspecified

SNOMEDCT:
50563003 – Seborrheic dermatitis

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The most difficult diagnoses to separate from infantile seborrheic dermatitis are atopic dermatitis and irritant contact dermatitis. Atopic dermatitis more often involves the scalp, cheeks, and extensor surfaces and is associated with a family history of other atopic conditions (asthma, allergic rhinitis). It is usually accompanied by moderate-to-severe pruritus that interferes with sleep and feeding, whereas infantile seborrheic dermatitis is asymptomatic. Irritant contact dermatitis (diaper dermatitis) caused by the irritant effects of urine and feces typically spares the deep body folds for lack of contact with the skin.

Psoriasis is extremely uncommon in neonates and infants. However, familial and genetically determined forms of psoriasis and other psoriasiform dermatitis do characteristically present with infantile psoriasis involving a similar distribution. The scaling is thicker in nonoccluded areas and plaques are better defined.

When localized in the diaper area, dermatoses to consider besides irritant contact dermatitis:

• Candidiasis
• Psoriasis – consider in those with particularly difficult-to-remove scales; examine the patient in locations characteristic for psoriasis
• Allergic contact dermatitis
• Tinea cruris - rare in infancy
• Intertrigo
• Langerhans cell histiocytosis
• Scabies
• Kawasaki disease
• Sexual abuse
• Acrodermatitis enteropathica
• Lichen sclerosus
• Perianal streptococcal infection
• Congenital syphilis

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Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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