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Seborrheic keratosis
See also in: External and Internal Eye,Anogenital,Hair and Scalp
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Seborrheic keratosis

See also in: External and Internal Eye,Anogenital,Hair and Scalp
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Contributors: Susan Burgin MD, Belinda Tan MD, PhD, Sarah Hocker DO, Noah Craft MD, PhD
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Synopsis

Seborrheic keratoses (SKs) are extremely common benign neoplasms of the epidermis that typically appear on the chest and the back. There can be few or hundreds of these raised, "stuck-on"-appearing papules and plaques with well-defined borders. The etiology is unknown, although there is a familial trait for the development of multiple SKs with an autosomal dominant mode of inheritance. SKs tend to increase in incidence and number with increasing age. They may start out as a flat wrinkled plaque with a "postage stamp" appearance (flat seborrheic keratosis). SKs are asymptomatic, but when irritated or traumatized, they may become pruritic or painful with associated redness or bleeding.  

A lichenoid keratosis is an inflamed seborrheic keratosis that presents as a pink shiny papule or plaque with an appearance that resembles that of a nodular or cystic basal cell cancer.

Dermatosis papulosa nigra is a term given to the papular seborrheic keratoses (most often seen as dark brown 1-3 mm papules) on the face of individuals with darker skin phototypes.

Relatively rapid onset of numerous SKs may be a cutaneous sign of internal malignancy. Multiple eruptive SKs in association with a visceral cancer is referred to as the sign of Leser-Trélat. The most common associated malignancy is adenocarcinoma of the gastrointestinal tract.

For more information, see OMIM.

Codes

ICD10CM:
L82.1 – Other seborrheic keratosis

SNOMEDCT:
25499005 – Seborrheic keratosis

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 01/31/2017
Last Updated: 03/29/2017
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Seborrheic keratosis
See also in: External and Internal Eye,Anogenital,Hair and Scalp
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Seborrheic keratosis : Verrucous scaly papule
Clinical image of Seborrheic keratosis
An inflamed seborrheic keratosis showing a substantive pink and gray, stuck-on, verrucous plaque with keratotic plugs on the surface.
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