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SynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences

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Seborrheic keratosis - Anogenital in
See also in: Overview,External and Internal Eye,Hair and Scalp
Other Resources UpToDate PubMed

Seborrheic keratosis - Anogenital in

See also in: Overview,External and Internal Eye,Hair and Scalp
Contributors: Susan Burgin MD, Belinda Tan MD, PhD, Callyn Iwuala MD, Oyetewa Oyerinde MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed

Synopsis

Seborrheic keratoses (SKs) are extremely common benign neoplasms of the epidermis that typically appear on the chest and the back. There can be a few or hundreds of these raised, "stuck-on"-appearing papules and plaques with well-defined borders. The etiology is unknown, although there is a familial trait for the development of multiple SKs with an autosomal dominant mode of inheritance. SKs tend to increase in incidence and number with increasing age. They may start out as a flat, wrinkled plaque with a "postage stamp" appearance (flat seborrheic keratosis). SKs are asymptomatic, but when irritated or traumatized, they may become pruritic or painful with associated redness or bleeding.

SKs are rarely seen on the penile skin. SKs in the genital area have been associated with the presence of human papillomavirus (HPV) infection as identified by polymerase chain reaction.

Codes

ICD10CM:
L82.1 – Other seborrheic keratosis

SNOMEDCT:
25499005 – Seborrheic keratosis

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Melanoma – For any dark or atypical appearing pigmented lesion, the diagnosis of melanoma should be ruled out.
  • Common acquired nevus
  • Genital wart may resemble SKs, but they usually manifest filiform (threadlike) or acuminate (pointed) excrescences. Older warts may lose some of these features. In cases of doubt, a biopsy should be performed.
  • Bowenoid papulosis
  • Squamous cell carcinoma in situ
  • Extramammary Paget disease
  • Acrochordon
  • Lichen planus
  • Psoriasis
  • Molluscum contagiosum
  • Fordyce spots
  • Angiokeratoma
  • Papular acantholytic dermatosis

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed:02/02/2017
Last Updated:01/24/2022
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Seborrheic keratosis - Anogenital in
See also in: Overview,External and Internal Eye,Hair and Scalp
A medical illustration showing key findings of Seborrheic keratosis : Verrucous scaly papule
Clinical image of Seborrheic keratosis - imageId=76731. Click to open in gallery.  caption: 'An inflamed seborrheic keratosis showing a substantive pink and gray, stuck-on, verrucous plaque with keratotic plugs on the surface.'
An inflamed seborrheic keratosis showing a substantive pink and gray, stuck-on, verrucous plaque with keratotic plugs on the surface.
Copyright © 2024 VisualDx®. All rights reserved.