Serum sickness-like reaction in Child
Alerts and Notices
Synopsis
Eosinophilia may be present, but unlike true serum sickness, immune complexes, hypocomplementemia, and vasculitis are not found. Most reactions are mild and self-limited and resolve within several days to weeks after drug withdrawal.
Antibiotics, particularly cefaclor, penicillins, and sulfonamides, nonsteroidal anti-inflammatory drugs (NSAIDs), allopurinol, propranolol, and carbamazepine are among the most frequent offenders.
Codes
ICD10CM:T80.69XA – Other serum reaction due to other serum, initial encounter
SNOMEDCT:
402658008 – Serum sickness type vasculitis
Look For
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Urticaria
- Erythema marginatum / rheumatic fever
- Eosinophilic cellulitis
- Neonatal lupus erythematosus
- Drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms [DRESS])
- Serum sickness
- Leukocytoclastic vasculitis
- Exanthematous drug eruption
- Hereditary angioedema
- Erythema multiforme
- Mononucleosis
- Urticarial vasculitis
- Immunoglobulin A vasculitis (formerly Henoch-Schönlein purpura)
- Cellulitis
- Erythema infectiosum
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:08/06/2018
Last Updated:12/13/2018
Last Updated:12/13/2018
Serum sickness-like reaction in Child