Solitary neurofibromas are are well-circumscribed, non-encapsulated, benign tumors of neuromesenchymal tissue (Schwann cells, perineural cells, fibroblasts, and mast cells) with nerve axons. They present as asymptomatic, skin-colored or violaceous, rubbery papules or nodules. They can occur anywhere on the body. Solitary neurofibromas occur primarily in adulthood and late adolescence and are not an indication of neurofibromatosis. There is no sex predilection.
ICD10CM: D21.9 – Benign neoplasm of connective and other soft tissue, unspecified
SNOMEDCT: 404030000 – Solitary neurofibroma
Differential Diagnosis & Pitfalls
– Should be ruled out with a complete cutaneous examination.