Solitary plasmacytoma of bone
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Synopsis
SPB makes up 1%-2% of plasma cell neoplasms and occurs more commonly in men, with a median age at diagnosis of 55 years. It is very rare under the age of 30.
Patients present with bone pain or pathologic fracture. If a vertebra is involved, spinal cord compression and associated symptoms may occur. Rarely, patients may present with a palpable mass involving surrounding soft tissue.
Codes
ICD10CM:C90.30 – Solitary plasmacytoma not having achieved remission
SNOMEDCT:
10639003 – Solitary plasmacytoma of bone
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Plasma cell neoplasm or multiple myeloma
- POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, multiple myeloma, and skin changes)
- Osteosarcoma
- Ewing sarcoma
- Osteomyelitis
- Amyloidoma
- Metastatic lesion to bone of solid primary tumor
- Infiltrative bone disease such as histiocytosis
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Management Pearls
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Therapy
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References
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Last Reviewed:09/09/2018
Last Updated:09/09/2018
Last Updated:09/09/2018