Approximately 10% of clinically recognized pregnancies end in a miscarriage, and 80% of these occur within the first trimester. It is estimated that about 50% of these losses are due to fetal chromosomal abnormalities.
Vaginal bleeding and uterine cramping are the main symptoms of pregnancy loss.
Risk factors for early pregnancy loss included advanced maternal age, history of prior pregnancy loss, endocrine abnormalities (eg, diabetes, thyroid disease), short intervals between pregnancies, infections, autoimmune diseases, and uterine anomalies.
Related topic: stillbirth
003.9 – Complete or unspecified spontaneous abortion without complication
17369002 – Miscarriage
Differential Diagnosis & Pitfalls
- Ectopic pregnancy – Pregnancy located outside of the uterus.
- Early viable intrauterine pregnancy – Viable pregnancy seen on ultrasound, or criteria has not been made for early pregnancy loss and it is too early in the pregnancy to see a yolk sac.
- Incomplete abortion – Retained products of conception after some initial vaginal bleeding.
- Missed abortion – Pregnancy tissue in uterus but criteria have been met for early pregnancy loss, or patient previously had viable intrauterine pregnancy and now has no cardiac activity.
- Threatened abortion – Vaginal bleeding in early pregnancy, closed cervical os, and diagnostic criteria for pregnancy loss has not been made.
Drug Reaction Data