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Potentially life-threatening emergency
Staphylococcus aureus pneumonia - Pulmonary
Other Resources UpToDate PubMed
Potentially life-threatening emergency

Staphylococcus aureus pneumonia - Pulmonary

Contributors: Susan Voci MD, Sumanth Rajagopal MD, William Bonnez MD
Other Resources UpToDate PubMed

Synopsis

Staphylococcus aureus are aerobic gram-positive cocci that form clusters and short chains. They are responsible for a wide variety of diseases ranging from superficial skin and soft tissue infections to deep-seated and life-threatening infections with high morbidity and mortality rates, such as endocarditis and septicemia. In addition, S aureus is capable of secreting toxins that mediate illnesses like the toxic shock syndrome (TSS) and the staphylococcal scalded skin syndrome (SSSS).

S aureus is a ubiquitous colonizer of the skin and mucosal surfaces and can be found in the nares of 10%-40% of individuals in the community and in the hospital. Nasal carriage is also a source for the transmission of multiresistant staphylococci. Certain patient populations like dialysis patients, people with diabetes, people who use IV drugs, people with alcohol use disorder, and HIV-infected individuals are at a high risk for infections from staphylococci.

Staphylococcus aureus in responsible for about 1%-10% of community-acquired pneumonias and 20–30% of hospital-acquired pneumonias. Staphylococcus aureus pneumonia may result from air-borne contamination or aspiration or hematogenous seeding of the lungs from bacteremia or right-sided endocarditis. There may be a history of recent viral or influenzal illness. The clinical manifestations of staphylococcal pneumonia are similar to other causes of pneumonia except for a tendency to cause necrotizing infection with tissue destruction and cavitation. The patient will present with an abrupt onset of fever, tachypnea, pleuritic chest pain, and a productive cough with purulent sputum, which can be blood-tinged. Staphylococcus aureus is also one of the most common causes of empyema. In cases with accompanying endocarditis, stigmata-like subungual hemorrhages, murmur of aortic, tricuspid or mitral regurgitation, palmar Janeway lesions, and digital Osler nodes may be found.

Methicillin-resistant S aureus (MRSA) first emerged as an important nosocomial pathogen in the 1960s. In more recent years, community-acquired outbreaks of MRSA (CA-MRSA) have been described increasingly among healthy individuals lacking the traditional risk factors for staphylococcal infections.

A rapidly progressive necrotizing pneumonia in young, healthy adults and children has been described due to infection with strains of CA-MRSA containing the gene for the Panton-Valentine leucocidin (PVL), a toxin that induces lysis of host macrophages, thus impairing host response and facilitating tissue necrosis. The mortality from pneumonias caused by the PVL strains is very high.

Codes

ICD10CM:
J15.211 – Pneumonia due to Methicillin susceptible Staphylococcus aureus

SNOMEDCT:
441658007 – Pneumonia due to Staphylococcus aureus

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Differential Diagnosis & Pitfalls

Other agents of community-acquired and hospital-acquired pneumonias like Streptococcus pneumoniae, Haemophilus influenzae, enteric gram-negative bacilli, and Legionella pneumophila cause syndromes that are clinically indistinguishable from staphylococcal pneumonia. A necrotizing process with tissue destruction and cavitation may suggest a staphylococcal etiology. A preceding viral illness or influenza followed by the pneumonic illness may also suggest staphylococcal infection.

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Last Updated:12/01/2020
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Potentially life-threatening emergency
Staphylococcus aureus pneumonia - Pulmonary
A medical illustration showing key findings of Staphylococcus aureus pneumonia : Fever, Pleuritic chest pain, Productive cough, RR increased
Imaging Studies image of Staphylococcus aureus pneumonia - imageId=2997983. Click to open in gallery.  caption: 'AP supine chest x-ray demonstrating a diffuse right-sided opacity which may be related to layering of a pleural effusion. In addition, there are poorly defined nodular opacities on the right, (long arrow). Endotracheal tube is present, (short arrow).'
AP supine chest x-ray demonstrating a diffuse right-sided opacity which may be related to layering of a pleural effusion. In addition, there are poorly defined nodular opacities on the right, (long arrow). Endotracheal tube is present, (short arrow).
Copyright © 2023 VisualDx®. All rights reserved.