Striae in Adult
Periods of rapid growth, such as puberty, pregnancy (striae gravidarum), training with weight lifting, rapid weight gain, and adolescent growth spurts, are common triggers. Striae also commonly occur in the setting of obesity. As 60%-70% of the US population is labeled as overweight or obese, the prevalence of striae from obesity is estimated at 40%. The skin findings themselves are rarely symptomatic, but they may occasionally indicate an underlying disease state (such as Cushing syndrome). In Marfan syndrome, striae are seen in around two-thirds of patients. Striae tend to flatten and become less conspicuous over time.
Bevacizumab, a vascular endothelial growth factor (VEGF) inhibitor, has been reported to cause ulceration of striae that have been induced by concurrent systemic glucocorticoid therapy.
Related topic: drug-induced skin ulcers
L90.6 – Striae atrophicae
201066002 – Skin striae
Differential Diagnosis & Pitfalls
- Anetoderma is caused by focal loss of elastic fibers within the dermis and presents as flaccid, well-circumscribed areas of slack skin. Sac-like protrusions can occasionally be observed in some lesions.
- Lichen sclerosus presents as flat, yellowish-white plaques surrounded by a red, purple, or violet border.
- Steroid atrophy may accompany striae caused by topical corticosteroids.
- Scars are raised, firm nodules or plaques at sites of previous trauma.
- Linear focal elastosis (elastotic striae) is a rare condition that presents as asymptomatic atrophic yellow lines on the mid- or lower back, thighs, arms, or breasts.
Drug Reaction Data