In subcutaneous fat necrosis, disintegration and destruction of the subcutaneous fat affects newborns (both full-term and premature) within the first 4 weeks of life. Skin lesions are typically not present at birth. Difficult labor and childbirth, perinatal hypothermia and perinatal hypoxia, maternal diabetes, seizures, and preeclampsia have all been associated with the development of these benign skin lesions, which spontaneously resolve over months. Infants are afebrile and without systemic symptoms.