Substance-induced sexual dysfunction
Alerts and Notices
Synopsis
This diagnosis is made based on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), criteria of a clinically significant sexual dysfunction that causes significant distress to the individual and the symptoms of which develop during or soon after substance intoxication or withdrawal or after exposure to a medication.
Incidence of this condition is likely underreported due to a variety of factors, including patient shame / embarrassment as well as acceptance that these side effects are an unavoidable part of treatment. It has been cited that as many as 50% of patients taking antipsychotic medications will have adverse sexual side effects, and somewhere between 25% and 80% of patients taking antidepressants may as well.
Men may complain of erectile dysfunction, premature or absent ejaculation, anorgasmia, and/or pain with intercourse. Women may complain of decreased lubrication / dryness, decreased engorgement, anorgasmia, pain with intercourse, and/or decreased libido.
See Drug Reaction Data for a list of substances.
Related topic: Drug-induced erectile dysfunction
Codes
ICD10CM:R37 – Sexual dysfunction, unspecified
SNOMEDCT:
425528008 – Sexual dysfunction due to substance
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Perimenopausal / menopausal transition
- Relationship issues
- Stress / fatigue
- Lactation
- Pregnancy
- Psychiatric disorders (eg, psychosexual disorder, depression, anxiety, eating disorders [anorexia nervosa], borderline personality disorder, schizophrenia)
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:06/12/2019
Last Updated:11/17/2019
Last Updated:11/17/2019
Substance-induced sexual dysfunction