The primary symptoms of the sympatholytic toxidrome are bradycardia, hypotension, and decreased respiratory rate. Patients may sometimes also present with altered mental status, dry skin, and miosis.
Treatment depends on the particular drug causing the overdose. For example, glucagon and calcium can be given for beta-blocker and calcium-channel blocker overdoses, respectively. IV fluids and vasopressors are frequently used to maintain adequate blood pressure.
T44.8X1A – Poisoning by centrally-acting and adrenergic-neuron-blocking agents, accidental (unintentional), initial encounter
218842006 – Adverse reaction to sympatholytic