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Syringocystadenoma papilliferum
Other Resources UpToDate PubMed

Syringocystadenoma papilliferum

Contributors: Amy Fox MD, David Dasher MD, Belinda Tan MD, PhD, Mary Gail Mercurio MD, Jeffrey D. Bernhard MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed


Syringocystadenoma papilliferum (syringadenoma papilliferum) is a benign adnexal neoplasm commonly found on the head and neck or within a nevus sebaceus. Other common locations include the genital and inguinal skin.

These tumors are commonly present at birth or develop within the first several years of life, and they tend to enlarge during puberty. Clinical presentation is variable including papules, plaques, and verrucous lesions. Serous drainage from these lesions is not uncommon, but most are asymptomatic.

A few cases of malignant transformation to syringocystadenocarcinoma papilliferum have been reported; thus, surgical excision should be considered.

Special considerations in infants: Roughly one-half of all syringocystadenoma papilliferum tumors are present at birth. One-third of them arise in a nevus sebaceus.


D23.4 – Other benign neoplasm of skin of scalp and neck

239121009 – Syringocystadenoma papilliferum

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Differential Diagnosis & Pitfalls

The differential diagnosis is very broad given the variable clinical presentation; histology is the primary method of establishing a diagnosis.
  • Nodular basal cell carcinoma / Cutaneous squamous cell carcinoma
  • Amelanotic melanoma
  • Other skin appendage tumors
  • Common wart
  • Molluscum contagiosum

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Last Updated:04/05/2022
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Syringocystadenoma papilliferum
A medical illustration showing key findings of Syringocystadenoma papilliferum : Erythema, Neck, Scalp, Tumor
Clinical image of Syringocystadenoma papilliferum - imageId=1031548. Click to open in gallery.  caption: 'A frambesiform pink nodule on the scalp.'
A frambesiform pink nodule on the scalp.
Copyright © 2024 VisualDx®. All rights reserved.