Tarsal tunnel syndrome is a condition caused by compression of the tibial nerve in the tarsal tunnel of the ankle and foot. This disorder is more prevalent in females than in males, predominantly in adults. Causes are intrinsic or extrinsic. Intrinsic causes include osteophytes, lipoma, tumor, and ganglion cysts. Extrinsic causes include trauma, tight-fitting shoes, lower limb edema, systemic inflammatory arthropathy, diabetes, and mucolipidoses. The most common cause of tarsal tunnel syndrome is trauma.

Symptoms include unilateral pain, numbness, burning, and tingling in the sole of the foot. Additionally, patients may experience pain in the distal foot, toes, and sometimes the heel. Often, the pain can radiate up to the calf. Pain is typically worse after long periods of standing and improves with rest and elevation. Pain is typically worse at night.