Nonseminomatous tumors most commonly occur in patients aged 15-35, while seminomatous tumors target men a decade older. Germ cell malignancies of the testis are typically associated with a specific cytogenic irregularity (il2p). Non-germ cell tumors may arise in Leydig or Sertoli cells, or lymphomas, with non-Hodgkin lymphoma more common in men over age 60.
Treatment depends on clinical staging and includes surveillance, chemotherapy, lymph node removal (nerve-sparing retroperitoneal lymph node dissection, or RPLND), adjuvant chemotherapy, orchiectomy, and radiation therapy.
C62.90 – Malignant neoplasm of unspecified testis, unspecified whether descended or undescended
363449006 – Malignant tumor of testis
Differential Diagnosis & Pitfalls