Traumatic eosinophilic granuloma - Oral Mucosal Lesion
The reported range of duration is from 1 week to 8 months.
K13.4 – Granuloma and granuloma-like lesions of oral mucosa
8090002 – Eosinophilic granuloma of oral mucosa
Differential Diagnosis & Pitfalls
- Behçet syndrome
- Aphthous ulcer
- Drug-induced oral ulcer
- Oral traumatic ulcer – Generally the routine traumatic ulcer is not as chronic as the traumatic granuloma, although candidal infection of the periphery of a traumatic ulcer may cause it to persist. Eosinophils are not typically observed histologically.
- Squamous cell carcinoma – This malignancy may appear to be very similar clinically, and biopsy is often necessary to distinguish between these two entities.
- Non-Hodgkin lymphoma – This malignancy, when secondarily ulcerated, can also appear clinically very similar to traumatic granuloma. Recent reports have suggested that a small percentage of lesions that may have been categorized as traumatic granuloma in the past could represent an indolent CD-30-positive T-cell lymphoma.
- Histoplasmosis or other deep fungal infection – Biopsy reveals Histoplasma capsulatum or other causative organisms in tissue sections stained with periodic acid-Schiff (PAS) or Grocott-Gömöri's methenamine silver (GMS) method.
- Tuberculous ulcer – Biopsy shows necrotizing granulomatous inflammation and acid-fast bacilli.