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Traumatic eosinophilic granuloma - Oral Mucosal Lesion
Other Resources UpToDate PubMed

Traumatic eosinophilic granuloma - Oral Mucosal Lesion

Contributors: Carl Allen DDS, MSD, Sook-Bin Woo MS, DMD, MMSc
Other Resources UpToDate PubMed


Traumatic eosinophilic granuloma is an interesting chronic ulceration of the oral mucosa that presumably has a traumatic etiology.

The lesions occur over a wide age range.

Symptoms are often surprisingly mild, but patients may report tenderness depending on the size and location of the ulcer.

Reported range of duration is from 1 week to 8 months.


K13.4 – Granuloma and granuloma-like lesions of oral mucosa

8090002 – Eosinophilic granuloma of oral mucosa

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Differential Diagnosis & Pitfalls

  • Behçet's syndrome
  • Aphthous ulcer
  • Drug-induced oral ulcer
  • Oral traumatic ulcer – Generally the routine traumatic ulcer is not as chronic as the traumatic granuloma, although candidal infection of the periphery of a traumatic ulcer may cause it to persist.
  • Squamous cell carcinoma – This malignancy may appear to be very similar clinically, and biopsy is often necessary to distinguish between these two entities.
  • Non-Hodgkin's lymphoma – This malignancy, when secondarily ulcerated, can also appear clinically very similar to traumatic granuloma. Recent reports have suggested that a small percentage of lesions that may have been categorized as traumatic granuloma in the past could represent an indolent CD-30-positive T-cell lymphoma.
  • Histoplasmosis or other deep fungal infection – Biopsy reveals Histoplasma capsulatum or other causative organisms in tissue sections stained with PAS or GMS method.
  • Tuberculous ulcer – Biopsy shows necrotizing granulomatous inflammation and acid-fast bacilli.

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Last Updated:06/17/2014
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Traumatic eosinophilic granuloma - Oral Mucosal Lesion
A medical illustration showing key findings of Traumatic eosinophilic granuloma : Oral ulcers, Oral erosions, Oral mucosa, Oral white plaque, EOS increased
Clinical image of Traumatic eosinophilic granuloma - imageId=2501567. Click to open in gallery.  caption: 'A slough-covered plaque on the mucosal lip.'
A slough-covered plaque on the mucosal lip.
Copyright © 2023 VisualDx®. All rights reserved.