ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyReferences
Trichoblastoma
Other Resources UpToDate PubMed

Trichoblastoma

Contributors: Amy E. Blum MA, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Trichoblastoma is a rare benign tumor that arises from the germ cells of the hair follicle. The characteristic clinical presentation is a solitary, asymptomatic nodule on the face or scalp. Trichoblastoma may occur sporadically, in association with a hereditary disease, or within a nevus sebaceus. Trichoblastoma occurs most often in adults in their fifth and sixth decades, although it may be seen outside this age group. It affects male and female individuals equally.

Trichoblastoma is closely related to trichoepithelioma, another benign follicular tumor that arises from follicular germ cells. Some experts consider trichoepithelioma to be a superficial variant of trichoblastoma; trichoepithelioma arises in the superficial dermis and trichoblastoma arises in the deep dermis and subcutis.

Trichoblastoma is one of the most common tumors to arise within a nevus sebaceus, a congenital hamartoma most often found on the scalp. Trichoblastomas have been reported to occur in Curry-Jones syndrome (patchy hypopigmentation, polysyndactyly, cranial defects, and ophthalmic and gastrointestinal abnormalities).

Malignant transformation of trichoblastoma into a trichoblastic carcinoma, trichoblastic sarcoma, or trichoblastic carcinosarcoma is exceedingly rare. Malignant transformation most commonly presents as a long-standing lesion that suddenly enlarges. There is limited available data concerning the behavior and prognosis of malignant trichoblastic neoplasms; however, distant spread and death have been reported, and this aggressive behavior may be more common in sporadic cases.

Codes

ICD10CM:
D23.9 – Other benign neoplasm of skin, unspecified

SNOMEDCT:
277942005 – Trichoblastoma

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

References

Subscription Required

Last Reviewed:04/20/2020
Last Updated:05/31/2020
Copyright © 2021 VisualDx®. All rights reserved.
Trichoblastoma
Print  
Trichoblastoma
Copyright © 2021 VisualDx®. All rights reserved.