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Trichoepithelioma in Adult
Other Resources UpToDate PubMed

Trichoepithelioma in Adult

Contributors: Daniel Gutierrez MD, Susan Burgin MD
Other Resources UpToDate PubMed


Trichoepitheliomas are benign neoplasms derived from the hair follicles. They usually present as asymptomatic smooth, skin-colored papules or nodules on the central face and scalp.

Various genetic syndromes can be associated with trichoepitheliomas. Mutations in CYLD on chromosome 9 are inherited in an autosomal-dominant pattern and can result in 3 distinct clinical phenotypes: Brooke-Spiegler syndrome, multiple familial trichoepitheliomas, and familial cylindromatosis. Both Brooke-Spiegler syndrome and multiple familial trichoepitheliomas are associated with development of multiple trichoepitheliomas in childhood or early adolescence. Because of decreased penetrance of this gene in men, such trichoepitheliomas are more commonly seen in female patients.

Desmoplastic trichoepithelioma (DTE) is a variant of trichoepithelioma that presents on the face as a slow-growing, skin-colored papule or plaque with a raised border and depressed center. DTEs are most commonly seen on the cheeks of young women. Solitary, multiple, familial, and nonfamilial presentations have been described. Inheritance patterns, however, are not well elucidated.

Related topic: Cylindroma


D23.30 – Other benign neoplasm of skin of unspecified part of face

274898000 – Trichoepithelioma

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Differential Diagnosis & Pitfalls

The differential diagnosis for trichoepitheliomas and DTEs includes the following:
  • Nodular basal cell carcinoma
  • Microcystic adnexal carcinoma
  • Common acquired nevus
  • Trichoblastoma
  • Syringoma
  • Cylindroma
  • Trichofolliculoma
  • Trichilemmoma
  • Angiofibroma
  • Epidermoid cyst
  • Sebaceous hyperplasia
  • Milia
  • Molluscum contagiosum (Molluscum contagiosum, Molluscum contagiosum )
  • Sarcoidosis – lupus pernio

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Last Reviewed:10/14/2019
Last Updated:10/31/2019
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Trichoepithelioma in Adult
A medical illustration showing key findings of Trichoepithelioma : Cheek, Nose, Superior lip, Smooth papules, Smooth nodules
Clinical image of Trichoepithelioma - imageId=5928829. Click to open in gallery.  caption: 'A large, smooth, shiny papule at the nasal alar crease.'
A large, smooth, shiny papule at the nasal alar crease.
Copyright © 2024 VisualDx®. All rights reserved.