Tumid lupus erythematosus
In general, TLE is a skin-limited condition. It is characterized histologically by a lymphocytic infiltrate of T-cells with a CD4:CD8 ratio of roughly 4:1, differentiating this from other clinical mimickers with predominant CD8 infiltration such as pseudolymphoma. Koebner phenomenon (isomorphic response) and relapses at sites of trauma have been reported.
Antinuclear antibody (ANA) positivity occurs in a very small subset of patients, and 10% of patients with systemic lupus erythematosus (SLE) will have lesions consistent with TLE. In addition, there have been a few reports of patients with TLE occurring with discoid lupus erythematosus. Females seem to be affected more frequently than males. The youngest reported patient to date was 16 years old.
L93.2 – Other local lupus erythematosus
200941006 – Lupus erythematosus tumidus
Differential Diagnosis & Pitfalls