Type 2 lepra reaction in Adult
Alerts and Notices
Synopsis

Patients present with sudden onset crops of painful, tender, and erythematous subcutaneous nodules that may subsequently ulcerate. The lesions are common on the face and extensor surfaces of the upper and lower extremities. In addition, there may be systemic signs such as fever, malaise, arthralgias, and myalgias. Other affected organs may include the eyes, kidneys, testes, and lymph nodes. Type 2 reactions are caused by immune complex formation and deposition. They typically are seen in patients with borderline lepromatous or polar lepromatous disease. Other risk factors for type 2 reactions include hormonal changes in women that come with puberty, pregnancy, and lactation. Reactions may last from days to weeks; they may recur or persist over months.
Prompt diagnosis and treatment of lepra reactions is necessary to prevent significant neurologic morbidity and disability.
Codes
ICD10CM:B92 – Sequelae of leprosy
SNOMEDCT:
240410002 – Type 2 lepra reaction
Look For
Subscription Required
Diagnostic Pearls
Subscription Required
Differential Diagnosis & Pitfalls
- Erythema nodosum – Typically affects the lower legs; lesions are less widespread than in type 2 lepra reaction.
- Acute febrile neutrophilic dermatosis (Sweet syndrome)
- Rheumatoid neutrophilic dermatosis
- Cutaneous polyarteritis nodosa
- Carbuncles
- Lucio phenomenon
- Diffuse cutaneous leishmaniasis – In endemic regions (see Old World and New World leishmaniasis).
Best Tests
Subscription Required
Management Pearls
Subscription Required
Therapy
Subscription Required
References
Subscription Required
Last Reviewed:01/15/2022
Last Updated:01/16/2022
Last Updated:01/16/2022