Type 2 lepra reaction in Adult
The type 2 reaction is also known as erythema nodosum leprosum. Patients present with sudden onset crops of painful, tender, and erythematous subcutaneous nodules that may subsequently ulcerate. The lesions are common on the face and extensor surfaces of the upper and lower extremities. In addition, there may be systemic signs such as fever, malaise, arthralgias, and myalgias. Other affected organs may include the eyes, kidneys, testes, and lymph nodes. Type 2 reactions are caused by immune complex formation and deposition. They typically are seen in patients with borderline lepromatous or polar lepromatous disease. Reactions may last from days to weeks; they may recur or persist over months.
Prompt diagnosis and treatment of lepra reactions is necessary to prevent significant neurologic morbidity and disability.
A30.9 – Leprosy, unspecified
240410002 – Type 2 lepra reaction
- Erythema nodosum – Typically affects lower legs; lesions less widespread than in type 2 lepra reaction.
- Sweet syndrome
- Rheumatoid neutrophilic dermatosis
- Cutaneous polyarteritis nodosa
- Lucio phenomenon
- Diffuse cutaneous leishmaniasis – In endemic regions. (See Old World and New World leishmaniasis.)
Last Updated: 09/01/2017