X-linked ichthyosis in Adult
The condition manifests as dirty-appearing scale on the trunk, extremities, and neck. The remainder of the trunk and extremities are also involved, with classic sparing of the face, palms, and soles, as well as the popliteal and antecubital fossae. This condition is exclusive to males and appears before 3 months of age, continuing lifelong. During the first few weeks of life there is desquamation of large, loosely adherent, translucent scales followed by the development of tightly adherent, dark-brown scales. There is no known racial, ethnic, or geographic predilection. It is worse in low-humidity climates.
For more information, see OMIM.
Q80.1 – X-linked ichthyosis
402771003 – X-linked recessive ichthyosis
- Ichthyosis vulgaris – Hyperlinear palms and soles, often associated with atopy.
- Eczema craquele
- Atopic dermatitis
- Acquired ichthyosis
- Lamellar ichthyosis – Tends to affect the entire skin surface, is usually more severe, and has ectropion, which X-linked ichthyosis lacks.
- Rare differential: ichthyosiform presentation of sarcoidosis.
- Allergic contact dermatitis or irritant contact dermatitis
- Drug eruption