X-linked ichthyosis in Child
This condition is almost exclusive to males, with exaggerated desquamation along the flanks of neonates being a common presentation. However, the disease phenotype ranges from absent to marked and diffuse scaling. Most commonly, the disease is diagnosed prenatally due to a low estriol on a maternal triple screen and confirmed by fluorescent in situ hybridization (FISH).
The placenta is of fetal origin and is also deficient in steroid sulfatase. For this reason, mothers with an affected child experience prolonged labor, possibly requiring cesarean section or vacuum-assisted delivery.
For more information, see OMIM.
Q80.1 – X-linked ichthyosis
402771003 – X-linked recessive ichthyosis
- Lamellar ichthyosis – May begin as a collodion membrane and involves the face, palms, soles, and flexural surfaces (ie, antecubital and popliteal fossae).
- Ichthyosis vulgaris – Hyperlinear palms and soles, often associated with atopy.
- Allergic contact dermatitis or irritant contact dermatitis
- Atopic dermatitis