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Acquired pancytopenia in Infant/Neonate
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Acquired pancytopenia in Infant/Neonate

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Contributors: Benjamin L. Mazer MD, MBA, Carla Casulo MD
Other Resources UpToDate PubMed


Pancytopenia is a deficiency in the production of all three bone marrow cell lines: erythroid, myeloid, and megakaryocytic. Patients will present with varying degrees of simultaneous anemia, leukopenia, and thrombocytopenia, respectively. Severe cases may cause fatigue or pallor (anemia), infection (leukopenia), or bleeding / petechiae (thrombocytopenia).

Acquired pancytopenia can be caused by bone marrow replacement from leukemia, metastatic carcinoma, myelodysplastic syndrome, or myeloproliferative diseases. Bone marrow failure, such as in aplastic anemia, may also lead to acquired pancytopenia. Severe malnutrition or malabsorption can rarely lead to pancytopenia.

Treatment depends on the underlying cause. Red blood cell and platelet transfusions can provide symptomatic treatment.


D61.818 – Other pancytopenia

5876000 – Acquired pancytopenia

Differential Diagnosis & Pitfalls

Pancytopenia can arise from:

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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Last Updated: 04/23/2019
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Acquired pancytopenia in Infant/Neonate
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Acquired pancytopenia : Fatigue, Bleeding time prolonged, Pancytopenia, Asthenia, Pallor, WBC decreased, PLT decreased, RBC decreased
Clinical image of Acquired pancytopenia
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