Acute interstitial nephritis
Alerts and Notices
Synopsis
Patients older than 65 appear to be more susceptible to developing AIN with medication exposures, most commonly to penicillins and cimetidine. Patients may or may not be symptomatic. Symptoms are related to the cause of AIN and to the degree of acute kidney injury. When drug induced, allergic-type symptoms of fever, rash, and eosinophilia may develop. Roughly half of patients with AIN develop oliguria.
AIN often resolves with withdrawal of the precipitating agent, with the degree of reversal in renal function dependent on the length of exposure and the extent of tubular damage.
Codes
ICD10CM:N12 – Tubulo-interstitial nephritis, not specified as acute or chronic
SNOMEDCT:
28637003 – Acute interstitial nephritis
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Diagnostic Pearls
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Differential Diagnosis & Pitfalls
- Volume responsive (pre-renal) acute kidney injury
- Acute tubular necrosis
- Post-infectious glomerulonephritis (eg, post-streptococcal glomerulonephritis)
Best Tests
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Management Pearls
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:01/30/2019
Last Updated:02/10/2019
Last Updated:02/10/2019