Aortitis is a potentially life-threatening inflammation of the aorta. Causes include trauma, bacterial or viral infection, connective tissue disease, and immune disorders. Common underlying causes include syphilis, giant cell arteritis, autoimmune vasculitis, polymyalgia rheumatica, and rheumatoid arthritis. Presentation is dependent on underlying cause, but patients can present with fever, chills, fatigue, myalgia, arthralgia, hypertension, chest pain, lower limb pain, or back pain. Neurologic symptoms can arise due to decreased cerebral blood flow and include headaches, vertigo, syncope, orthostasis, and convulsions. Rarely, gas may be seen within the aorta related to gastrointestinal disease with Clostridium septicum. Management involves treating the underlying cause to stop inflammation, treating any complications, and preventing relapse.