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Aplastic anemia in Adult
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Aplastic anemia in Adult

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Contributors: Mary Anne Morgan MD
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Synopsis

Rare anemia caused by a disorder of hematopoietic stem cells (bone marrow failure) that presents as hypocellular bone marrow and pancytopenia. Characterized by anemia, neutropenia, and thrombocytopenia absent splenomegaly. Clinical findings include progressive anemia, fatigue, dyspnea, and cardiopulmonary compromise. Complications may be life-threatening and include severe neutropenia, hemorrhage (menorrhagia, gingival bleeding, easy bruising), and recurring infection. Acquired cases may be idiopathic or associated with adverse effects of drugs, chemotherapy and radiation, exposure to chemical toxins, severe viral infections, and immune disorders. Inherited cases may be related to several genetic disorders, most commonly Fanconi anemia.

Prognosis varies with degree of severity and damage, with a high risk of death from infection. Management includes careful monitoring and prevention of life-threatening complications, immunosuppressive therapy, bone marrow or hematopoietic cell transplantation from compatible sibling donor, and antilymphocyte globulin.

For more information, see OMIM.

Codes

ICD10CM:
D61.9 – Aplastic anemia, unspecified

SNOMEDCT:
306058006 – Aplastic Anemia

Best Tests

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated: 03/29/2017
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Aplastic anemia in Adult
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Aplastic anemia : Fatigue, Easy bruising, Dyspnea, Menorrhagia, Pallor, Gingival bleeding, WBC decreased, PLT decreased, RBC decreased
Clinical image of Aplastic anemia
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