Diacetyl is a flavoring compound often used in e-cigarettes / vape pens. Its former use in factories manufacturing microwave popcorn was associated with diagnoses of bronchiolitis obliterans, thus sometimes known as "popcorn lung."
The clinical syndrome manifests as an airway obstruction, cough, and slowly progressive dyspnea (weeks to months), with radiographic examination showing normal or hyperinflation of the lungs. Tachypnea, crackles, and/or wheezing may be evident on physical examination.
Related topic: Bronchiolitis
J42 – Unspecified chronic bronchitis
40100001 – Obliterative bronchiolitis
Differential Diagnosis & Pitfalls
Drug Reaction Data