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Cold agglutinin disease
Other Resources UpToDate PubMed

Cold agglutinin disease

Contributors: Michael W. Winter MD, Benjamin L. Mazer MD, MBA
Other Resources UpToDate PubMed

Synopsis

A rare blood disorder that is a form of autoimmune hemolytic anemia. Caused by cold agglutinin antibodies (usually IgM antibodies) directed against antigens on the surface of red blood cells, resulting in premature hemolysis and anemia. Agglutination is activated by cold temperatures. May be primary or secondary.

Codes

ICD10CM:
D59.1 – Other autoimmune hemolytic anemias

SNOMEDCT:
398937006  – Cold autoimmune hemolytic anemia

Differential Diagnosis & Pitfalls

Best Tests

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Updated:05/18/2016
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Cold agglutinin disease
Cold agglutinin disease : Fatigue, Cold agglutinins elevated, Coombs test positive, Cold sensitivity, Dyspnea, RBC decreased
Clinical image of Cold agglutinin disease
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