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Cold agglutinin disease
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Cold agglutinin disease

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Contributors: Michael W. Winter MD, Benjamin L. Mazer MD, MBA
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Synopsis

A rare blood disorder that is a form of autoimmune hemolytic anemia. Caused by cold agglutinin antibodies (usually IgM antibodies) directed against antigens on the surface of red blood cells, resulting in premature hemolysis and anemia. Agglutination is activated by cold temperatures. May be primary or secondary.

Codes

ICD10CM:
D59.1 – Other autoimmune hemolytic anemias

SNOMEDCT:
398937006  – Cold autoimmune hemolytic anemia

Differential Diagnosis & Pitfalls

Best Tests

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References

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Last Updated: 05/18/2016
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Cold agglutinin disease
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Cold agglutinin disease : Fatigue, Cold agglutinins elevated, Coombs test positive, Cold sensitivity, Dyspnea, RBC decreased
Clinical image of Cold agglutinin disease
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