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Connective tissue nevi in Child
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Connective tissue nevi in Child

Contributors: Amy Fox MD, David Dasher MD, Lowell A. Goldsmith MD, MPH
Other Resources UpToDate PubMed

Synopsis

Connective tissue nevi consist of excessive production of normal tissue, ie, collagen (collagenomas), elastin (elastomas), and glycosaminoglycans (nevus mucinosis). Connective tissue nevi may be present at birth or arise during childhood and can be found anywhere on the body. They may be hereditary or acquired.

Connective tissue nevi have been described in association with tuberous sclerosis (shagreen patches are a form) and in a familial cutaneous collagenoma syndrome. Shagreen patches of tuberous sclerosis tend to develop during childhood and are rare at birth.

When found on the plantar surface, the nevi may be part of the Proteus syndrome. They have also been associated with multiple endocrine neoplasia (MEN1). Buschke-Ollendorf elastomas are another form of connective tissue hamartoma associated with benign bony lesions. Nevus mucinosis is a form of connective tissue nevi seen with Hunter syndrome.

Acquired collagenoma (athlete's nodules) may occur at sites of sporting injuries, such as the feet, knuckles, or knees.

Codes

ICD10CM:
D23.9 – Other benign neoplasm of skin, unspecified

SNOMEDCT:
400091006 – Connective tissue nevus

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Last Updated:09/10/2020
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