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Connective tissue nevi in Infant/Neonate
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Connective tissue nevi in Infant/Neonate

Contributors: Ahmet Yildirim MEd, Erica Ghareeb MD, William Farmer MD, Susan Burgin MD
Other Resources UpToDate PubMed

Synopsis

Connective tissue nevi (CTN) are hamartomas that consist of excessive production of normal tissue, such as collagen (collagenomas), elastin (elastomas), or both, glycosaminoglycans (nevus mucinosis), and fibroblasts (fibroblastic CTN). CTN may be present at birth or arise during childhood and can be found anywhere on the body. They are usually hereditary but may be acquired.

CTN may be isolated or occur as part of a syndrome, such as tuberous sclerosis (collagenomas known as shagreen patches and fibrous forehead plaque), familial cutaneous collagenomas, Proteus syndrome (cerebriform connective tissue nevus), and Buschke-Ollendorff syndrome (elastomas known as dermatofibrosis lenticularis disseminata). Acquired collagenoma (athlete's nodules) may occur at sites of sporting injuries, such as the feet, knuckles, or knees.

CTN have a variable clinical appearance. They may appear as skin-colored, light brown, or yellowish papules or plaques with a smooth, cobblestone, or peau d'orange surface.

Codes

ICD10CM:
D23.9 – Other benign neoplasm of skin, unspecified

SNOMEDCT:
400091006 – Connective tissue nevus of skin

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Collagenoma:
Dermatofibrosis lenticularis disseminata:
Mucinous nevus:
Fibroblastic CTN:

Best Tests

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Management Pearls

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Therapy

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References

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Last Reviewed:05/25/2021
Last Updated:06/02/2021
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Connective tissue nevi in Infant/Neonate
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Clinical image of Connective tissue nevi
Copyright © 2021 VisualDx®. All rights reserved.