Diabetes mellitus type 1
Patients may present with symptoms of hyperglycemia such as weight loss, polyuria, polydipsia, fatigue, nocturnal enuresis, and blurry vision. T1DM patients may present with diabetic ketoacidosis (DKA), a state of severe dehydration and acidemia due to insulin deficiency. Symptoms include abdominal pain, nausea, emesis, inattention, confusion, and even coma in the setting of hyperglycemia and elevated anion gap. DKA is often associated with compensatory hyperventilation (Kussmaul respiration) in the setting of primary metabolic acidosis and a fruity breath odor.
T1DM is very rare in some third-world countries, and an increasing incidence may be associated with modernization and advanced public health systems. T1DM is most common in Scandinavia and Northern Europe. China and parts of South America have the lowest incidence. The pathogenesis appears to be rooted in a genetic component that interacts with an environmental insult in most cases. An early study suggests that teplizumab delayed progression to clinical type 1 diabetes in genetic high-risk populations.
For more information, see OMIM.
Related topics: Diabetes mellitus type 2, Diabetic retinopathy, Diabetic dermopathy, Diabetic nephropathy, Diabetic neuropathy, Diabetic hyperosmolar syndrome, Neurogenic ulcer, Bullosis diabeticorum, Diabetic vulvitis
E10.9 – Type 1 diabetes mellitus without complications
46635009 – Diabetes Mellitus Type I
- Type 2 diabetes mellitus
- MODY – maturity onset diabetes of the young, also known as monogenic diabetes
- Hormonal tumors and secondary hyperglycemia (pheochromocytoma, Cushing syndrome, acromegaly, glucagonoma)
- Secondary hyperglycemia due to glucocorticoid use
- Addison disease
- Graves disease
- Hashimoto thyroiditis
- Chronic pancreatitis
- Thiazide diuretics, phenytoin leading to reduced insulin secretion / drug-induced hyperglycemia
- Vitamin B12 deficiency
- Alcohol use disorder
- Cystic fibrosis
Last Updated: 08/30/2019