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Potentially life-threatening emergency
Diabetic ketoacidosis
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Other Resources UpToDate PubMed
Potentially life-threatening emergency

Diabetic ketoacidosis

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Contributors: Joon B. Kim BS, Catherine Moore MD, Abhijeet Waghray MD
Other Resources UpToDate PubMed

Synopsis

Diabetic ketoacidosis (DKA) is a life-threatening acute metabolic complication of diabetes, in which the reduced effective action of circulating insulin combined with upregulation of counterregulatory hormones leads to hyperglycemia and uncontrolled oxidation of fatty acids into ketone bodies. This results in hyperosmolality and usually a severe anion gap metabolic acidosis.

Symptoms have a rapid onset (< 24 hours) and include polyuria, polydipsia, lethargy, and abdominal pain. The hyperosmolality can cause neurologic symptoms, such as mental obtundation and coma.

The treatment of DKA includes the correction of electrolyte and fluid abnormalities along with the administration of insulin.

Codes

ICD10CM:
E13.10 – Other specified diabetes mellitus with ketoacidosis without coma

SNOMEDCT:
420422005 – Ketoacidosis in diabetes mellitus

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 02/22/2019
Last Updated: 03/05/2019
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Potentially life-threatening emergency
Diabetic ketoacidosis
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Diabetic ketoacidosis (Adult) : Nausea/vomiting, Diffuse abdominal pain, Hyperglycemia, Metabolic acidosis, Hypohidrosis, HR increased, BP decreased, RR increased, WBC elevated, Na decreased, Confusion
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