Potentially life-threatening emergency
Disseminated candidiasis in Adult
Alerts and Notices
Synopsis

Systemic involvement can include acute candidal pyelonephritis, central nervous system (CNS) candidiasis, cardiovascular impairment, respiratory distress, altered consciousness, and severe diarrhea. Thrush is often present in the oropharynx in sepsis, but the presence of thrush in HIV-infected patients does not imply sepsis.
In most cases of Candida sepsis, the individual's own GI tract is the source of infection. Skin invasion from macerated intertriginous regions, intravenous (IV) lines, and IV drug abuse are other potential sources. Nosocomial infection with some Candida species (eg, Candida auris) has been associated with prolonged use of axillary temperature monitors. The vast majority of invasive candidiasis is caused by Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, and Candida krusei. Candida albicans is the usual species, but C glabrata is often seen, and C tropicalis is often implicated in leukemic patients.
Candida auris is an emerging cause of candidemia that is notable for high rates of mortality and for drug resistance. See below and the US Centers for Disease Control and Prevention (CDC) Information for Laboratorians and Health Professionals for more detailed information.
Codes
ICD10CM:B37.7 – Candidal sepsis
SNOMEDCT:
70572005 – Disseminated candidiasis
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Therapy
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Drug Reaction Data
Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.Subscription Required
References
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Last Reviewed:03/22/2023
Last Updated:03/23/2023
Last Updated:03/23/2023