Disseminated candidiasis in Child
Organ systems commonly affected include the kidneys, with over half of patients manifesting some form of renal involvement, which may include candiduria, hypertension, renal failure, abscess formation, and the development of fungal balls leading to obstruction and hydronephrosis. Central nervous system (CNS) involvement is also frequent, occurring in one-third of cases, and may result in abscess formation. Endophthalmitis is seen in almost half of all cases.
Cutaneous manifestations of systemic Candida infection include a generalized dermatitis, which may be followed by desquamation. Other common skin findings range from discrete pustules and erythematous or pink papules to nodules and necrotic skin. Macules may also be present. Chorioretinitis is characteristic.
Generalized symptoms include spiking fevers, chills, headache, hypotension, respiratory distress, blurred vision, and prostration. Myalgias, arthralgias, and osteoarthritis may be present. Pneumonia occurs in 70% of patients.
Systemic candidiasis is a serious illness that is associated with significant morbidity and mortality.
Candida auris is an emerging cause of candidemia that is notable for high rates of mortality and for drug resistance. See below and the US Centers for Disease Control and Prevention (CDC) Information for Laboratorians and Health Professionals for more detailed information.
B37.7 – Candidal sepsis
70572005 – Disseminated candidiasis
Differential Diagnosis & Pitfalls
Drug Reaction Data