ContentsSynopsisCodesLook ForDiagnostic PearlsDifferential Diagnosis & PitfallsBest TestsManagement PearlsTherapyDrug Reaction DataReferences
Drug-induced dyspepsia
Print
Other Resources UpToDate PubMed

Drug-induced dyspepsia

Print Images (1)
Contributors: Amirah Khan MD, Paritosh Prasad MD
Other Resources UpToDate PubMed

Synopsis

Dyspepsia is defined as epigastric pain lasting for at least 1 month that can be associated with epigastric fullness, nausea, vomiting, or heartburn. Dyspepsia can be caused by Helicobacter pylori infection, esophagitis, peptic ulcer disease, and gastroesophageal reflux disease (GERD) and can be worsened by medications, cigarette smoking, and alcohol. Functional dyspepsia is the term used for patients when endoscopy and other diagnostic tests have ruled out organic pathology.

The most common drugs that cause dyspepsia include aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), which can contribute to mucosal damage, ulceration, and bleeding complications. Other associated medications include iron, antibiotics, antihypertensives, narcotics, estrogens, theophylline, selective serotonin reuptake inhibitors (SSRIs), niacin, digoxin, corticosteroids, levodopa, and hypoglycemic agents. These medications can cause symptoms by causing direct gastric mucosal injury (eg, NSAIDs), a change in gastrointestinal sensorimotor function, worsening GERD, or idiopathic mechanisms.

Management of drug-induced dyspepsia includes drug discontinuation, assessment of underlying pathology, and symptom control.

Codes

ICD10CM:
T50.995A – Adverse effect of other drugs, medicaments and biological substances, initial encounter

SNOMEDCT:
299969005 – Drug-induced dyspepsia

Look For

Subscription Required

Diagnostic Pearls

Subscription Required

Differential Diagnosis & Pitfalls

Best Tests

Subscription Required

Management Pearls

Subscription Required

Therapy

Subscription Required

Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

Subscription Required

References

Subscription Required

Last Reviewed: 01/04/2019
Last Updated: 01/15/2019
Copyright © 2019 VisualDx®. All rights reserved.
Drug-induced dyspepsia
Print 1 Images
Drug-induced dyspepsia : Nausea/vomiting, Epigastric pain, Dyspepsia
Copyright © 2019 VisualDx®. All rights reserved.