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Gastric hypochlorhydria
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Gastric hypochlorhydria

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Contributors: Abhijeet Waghray MD, Christine Osborne MD, Khaled Bittar MD, Nishant H. Patel MD, Desiree Rivera-Nieves MD, Paritosh Prasad MD
Other Resources UpToDate PubMed

Synopsis

Gastric hypochlorhydria, or achlorhydria, refers to a decrease in hydrochloric acid secretion in the stomach. Its causes include gastric bypass surgery, Helicobacter pylori infection, proton pump inhibitor use, or pernicious anemia.

Patients with gastric hypochlorhydria undergo replacement of the usual gastric mucosa by intestinal-type cells, which may lead to cellular atypia and neoplasia. Patients with gastric hypochlorhydria may present with anemia, bloating, or vitamin deficiencies.

Gastric hypochlorhydria occurs equally across sexes and races and increases in prevalence with age. An association with intestinal metaplasia has also been established.

Codes

ICD10CM:
K30 – Functional dyspepsia

SNOMEDCT:
55961006 –  Hypochlorhydria

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

  • Partial gastrectomy
  • Atrophic gastritis
  • Achlorhydria
  • Mucolipidosis type IV
  • VIPomas

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 01/23/2018
Last Updated: 01/29/2018
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Gastric hypochlorhydria
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Gastric hypochlorhydria : Iron deficiency anemia, Proton pump inhibitor, Dyspepsia
Copyright © 2019 VisualDx®. All rights reserved.