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Glomerulonephritis
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Glomerulonephritis

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Contributors: Peter Joo, Christine Osborne MD, Michael W. Winter MD
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Synopsis

Glomerulonephritis is inflammation of the glomerular capillaries from immune complex deposition (ie, immunoglobulin A [IgA] nephropathy), autoimmune activation, or inflammatory agents secreted by bacteria, viruses, or fungi, leading to damage of glomerular cells. Progressive damage leads to worsening renal function caused by interstitial nephritis, fibrosis, and tubular atrophy.

Patients typically present with hematuria, dysmorphic red blood cells on urine microscopy, proteinuria from mild to nephrotic range, edema, hypertension, and decline in renal function. This disease frequently affects young adults and is the most common cause of end-stage renal disease in this population.

There are groups of glomerulonephritis that can be classified based on clinical presentations, with overlap among groups depending on presentation: Related topic: Membranous glomerulonephritis

Codes

ICD10CM:
N00.9 – Acute nephritic syndrome with unspecified morphologic changes

SNOMEDCT:
36171008 – Glomerulonephritis

Look For

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Diagnostic Pearls

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Differential Diagnosis & Pitfalls

Most clinical and laboratory findings in the workup for glomerulonephritis portend a wide differential diagnosis. These include: There are a number of causes of glomerulonephritis (see Synopsis above).

Best Tests

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Management Pearls

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Therapy

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Drug Reaction Data

Below is a list of drugs with literature evidence indicating an adverse association with this diagnosis. The list is continually updated through ongoing research and new medication approvals. Click on Citations to sort by number of citations or click on Medication to sort the medications alphabetically.

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References

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Last Reviewed: 03/28/2019
Last Updated: 08/09/2019
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Glomerulonephritis
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Glomerulonephritis (Acute) : Dark urine, Facial edema, Fatigue, Creatinine elevated, Hematuria, Malaise, Proteinuria, RBC casts, Anorexia, Peripheral leg edema, Hypertension
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